Publications and Presentations | Peng Liu, PhD, Lab

Outputs

Peer-Reviewed Journal Articles

(corresponding author role for Liu italicized)

Peng Liu, Ian P. Lapcinski, Chris J.W. Hlynialuk, Elizabeth L. Steuer, Thomas J. Loude, Jr., Samantha L. Shapiro, Lisa J. Kemper, Karen H. Ashe. “Aβ*56 is a stable oligomer that impairs memory function in mice.” iScience 27(3):109239. 2024

Elizabeth L. Steuer, Lisa J. Kemper, Chris J.W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, and Peng Liu. “Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia.” J Neurosci 42(23):4737-54. 2022

Gurpreet Singh, Peng Liu, Katherine R. Yao, Jessica M. Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J. Teravskis, Jessica M. Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M. Nelson, Dezhi Liao, Karen H. Ashe, Michael A. Walters, and Steffen Pockes. “Caspase-2 inhibitor blocks tau truncation and restores excitatory neurotransmission in neurons modeling FTDP-17 tauopathy.” ACS Chem. Neurosci 13(10):1549-57. 2022

Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, and Steffen Pockes. “Structure-based design and biological evaluation of novel caspase-2 inhibitors based on the peptide AcVDVAD-CHO and the caspase-2-mediated tau cleavage sequence YKPVD314.” ACS Pharmacol Transl Sci 5(1):20-40. 2022

Peng Liu, Karen H. Ashe. “The molecular implications of a caspase-2-mediated sitespecific tau cleavage in tauopathies.” Neural Regen Res 16(9):1774-5. 2021

Peng Liu, Benjamin R. Smith, Michelle L. Montonye, Lisa J. Kemper, Kailee LeinonenWright, Kathryn M. Nelson, LeeAnn Higgins, Candace R. Guerrero, Todd W. Markowski, Xiaohui Zhao, Ashley J. Petersen, David S. Knopman, Ronald C. Petersen, Karen H. Ashe. “A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals.” Sci Rep 10:3869. 2020

Peng Liu, Benjamin R. Smith, Eric S. Huang, Abhishek Mahesh, Jean Paul G. Vonsattel, Ashley J. Petersen, Rocio Gomez-Pastor, Karen H. Ashe. “A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients.” Acta Neuropathol Com 7:111. 2019

Marianne K. O. Grant, Samantha L. Shapiro, Karen H. Ashe, Peng Liu, Kathleen R. Zahs. “A cautionary tale: endogenous biotinylated proteins and exogenously-introduced protein A cause antibody-independent artefacts in Western blot studies of brain-derived proteins.” Biol Proced Online 21:6. 2019

Marianne K. O. Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H. Ashe, Kathleen R. Zahs, Peng Liu. “Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.” PLoS ONE 14(2): e0212815. 2019

Peng Liu, John H. Reichl, Eshaan R. Rao, Brittany M. McNellis, Eric S. Huang, Laura S. Hemmy, Colleen L. Forster, Michael A Kuskowski, David R. Borchelt, Robert Vassar, Karen H. Ashe, Kathleen R. Zahs. “Quantitative comparison of dense-core amyloid plaque accumulation in amyloid-β precursor protein transgenic mice.” J Alzheimers Dis. 56(2): 743-61. 2017

Peng Liu, Arthur H. Robbins, Melissa R. Marzahn, Scott H. McClung, Charles A. Yowell, Stanley M. Stevens Jr., John B. Dame, Ben M. Dunn. “Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei.” PLoS ONE 10(10): e 0141758. 2015 (Highlighted by World Biomedical Frontiers [ISSN: 2328-0166], Infection and Immunity section, Mar-Apr 2016)

Peng Liu, Miranda N. Reed, Linda A. Kotilinek, Marianne K.O. Grant, Colleen L. Forster, Wei Qiang, Samantha L. Shapiro, John H. Reichl, Angie C.A. Chiang, Joanna L. Jankowsky, Carrie M. Wilmot, James P. Cleary, Kathleen R. Zahs, Karen H. Ashe. “Quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration.” Cell Rep 11(11): 1760-71. 2015

Peng Liu, Jennifer B. Paulson, Colleen L. Forster, Samantha L. Shapiro, Karen H. Ashe, Kathleen R. Zahs. “Characterization of a novel mouse model of Alzheimer's disease amyloid pathology and unique β-amyloid oligomer profile.” PLoS ONE 10(5): e0126317. 2015 Nadia Vaiana, Melissa R. Marzahn, Silvia Parapini, Peng Liu, Mario Dell’Agli, Andrea Pancotti, Enrico Sangiovanni, Nicoletta Basilico, Enrica Bosisio, Ben M. Dunn, Donatella Taramelli, Sergio Romeo. “Antiplasmodial activities of 4-aminoquinoline–statine compounds.” Bioorg Med Chem Lett 22(18): 5915-8. 2012

Peng Liu, Lisa J. Kemper, Jun Wang, Kathleen R. Zahs, Karen H. Ashe and Giulio M. Pasinetti. “Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice.” J Alzheimers Dis 26(4): 657-66. 2011

Miranda N. Reed, Peng Liu, Linda A. Kotilinek and Karen H. Ashe. “Effect size of reference memory deficits in the Morris water maze in Tg2576 mice.” Behav Brain Res 212(1): 115-20. 2010

Peng Liu, Melissa R. Marzahn, Arthur H. Robbins, Hugo Gutiérrez-de-Terán, David Rodríguez, Scott H. McClung, Stanley M. Stevens Jr., Charles A. Yowell, John B. Dame, Robert McKenna and Ben M. Dunn. “Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: Enzymatic characterization, active site inhibitor design, and structural analysis.” Biochemistry 48(19): 4086-99. 2009

Hugo Gutiérrez-de-Terán, Martin Nervall, Karolina Ersmark, Peng Liu, Linda K. Janka, Ben M. Dunn, Anders Hallberg and Johan Åqvist. “Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum.” Biochemistry 45(35): 10529-41. 2006

Mario Dell’Agli, Silvia Parapini, Germana Galli, Nadia Vaiana, Donatella Taramelli, Anna Sparatore, Peng Liu, Ben M. Dunn, Enrica Bosisio, Sergio Romeo. “High antiplasmodial activity of novel plasmepsin I and II inhibitors.” J Med Chem 49(25): 7440-9. 2006

Invited Talks, Conference Proceedings and Presentations

Invited Talks

Peng Liu. “Caspase-2-mediated Tau Cleavage and Dementia in Neurodegenerative Disorders.” 2021 University of Minnesota Department of Neurology Grand Rounds

Peng Liu. “The molecular implications of a caspase-2-mediated site-specific tau cleavage in neurodegenerative disorders.” 2020 A Virtual Conference: 4th Quarter Intercontinental Summit on Aging & Gerontology Conference

Conference Proceedings and Presentations

(presenting author role for Liu italicized)

Peng Liu, Elizabeth L. Steuer, Lisa J. Kemper, Kailee Leinonen-Wright, Michelle L. Montonye, Chris J.W. Hlynialuk, Julia E. Gamache, Karen H. Ashe. “Site-specifically blocking caspase-2-mediated tau cleavage delays cognitive impairment and brain atrophy in precisely engineered tau transgenic mice modeling frontotemporal dementia.” 2021 (Abstract initially published at the 15th International Conference on Alzheimer’s & Parkinson’s Diseases (ADPD) virtual conference, 2021.)

Peng Liu, Lisa J. Kemper, Peter J. Teravskis, Chris J.W. Hlynialuk, Benjamin R. Smith, Julia E. Gamache, Kailee Leinonen-Wright, Dezhi Liao, Keith A. Vossel, and Karen H. Ashe. “Site-specific blockage of caspase-2-mediated endogenous tau processing ameliorates deficits in amyloid precursor protein transgenic mice modeling Alzheimer’s disease.” 2020 (Abstract initially published at the Alzheimer's Association International Conference (AAIC) Neuroscience Next virtual conference, 2020.)

Karen H. Ashe, Peng Liu, Julia Gamache, Peter J. Teravskis, Chris Hlynialuk, Kailee Leinonen-Wright, Michael D. Koob, Dezhi Liao, Keith Vossel. “Reduced caspase-2 cleavage of endogenous tau ameliorates APP-induced deficits in an Alzheimer’s disease Peng Liu 651.202.6952 [email protected] 5 | Page mouse model.” 2019 (Abstract initially published at the 14th International Conference on Alzheimer’s & Parkinson’s Diseases (ADPD), Lisbon, Portugal, 2019.)

Peng Liu, Marianne K.O. Grant, Maureen Handoko, Gunnar Brinkmalm, Erik Portelius, Malgorzata Rozga, Kaj Blennow, Karen H. Ashe, Kathleen R. Zahs. “Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.” 2019 (Abstract initially published at the 14th International Conference on Alzheimer’s & Parkinson’s Diseases (ADPD), Lisbon, Portugal, 2019.)

Benjamin R Smith, Kathryn Nelson, Peng Liu, Margaret E Flanagan, Dirk Keene, Karen H. Ashe. “A tau cleavage product, Δtau314, is increased in Alzheimer’s disease and Parkinson’s disease with dementia.” Alzheimers Dement 14(7), Supplement: P1141-1142. 2018 (Abstract initially published at the Alzheimer's Association International Conference (AAIC), Chicago, 2018.)

Karen H. Ashe, Peng Liu, Miranda N. Reed, Marianne K.O. Grant, Colleen L. Forster, Wei Qiang, Samantha L. Shapiro, Joanna L. Jankowsky, Carrie M. Wilmot, James P. Cleary, Kathleen R. Zahs. “Type 1 and type 2 Aβ oligomers in the brain.” Neurobiol Aging 39(S1): S26. 2016 (Abstract initially published at the 14th International Athens/Springfield Symposium on Advances in Alzheimer Therapy (AAT), Athens, Greece, 2016.)

Peng Liu, Fatou Amar, Sylvain E. Lesné, Karen H. Ashe. “Cellular prion protein interacts with type 2 Aβ oligomers and mediates plaque-associated cytopathology in a transgenic mouse model of Alzheimer’s disease.” Alzheimers Dement 11(7), Supplement: P504. 2015 (Abstract initially published at the Alzheimer's Association International Conference (AAIC), Washington D.C., 2015.)

Kathleen R. Zahs, Peng Liu, Laura S. Hemmy, John H. Reichl, Eshaan Rao, Colleen L. Forster, Robert J. Vassar, David R. Borchelt, Karen H. Ashe. “Quantitative comparison of dense-core amyloid plaque burdens in Alzheimer’s disease patients and amyloid precursor protein transgenic mice.” Alzheimers Dement 11(7): P353. 2015 (Abstract initially published at the Alzheimer's Association International Conference (AAIC), Washington D.C., 2015.)

Peng Liu, Miranda N. Reed, Linda A. Kotilinek, Marianne K.O. Grant, Angie C. A. Chiang, Wei Qiang, Joanna L. Jankowsky, James P. Cleary, Kathleen R. Zahs, Karen H. Ashe. “Quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration.” Neurodegener Dis 15(S1): 376. 2015 (Abstract initially published at the 12th International Conferences on Alzheimer’s and Parkinson’s diseases, Nice, France, 2015.)

Karen Ashe, Peng Liu, Miranda N. Reed, Linda A. Kotilinek, Marianne K.O. Grant, Colleen L. Forster, Wei Qiang, John H. Reich, James P. Cleary, Kathleen R. Zahs. “The relevance of quaternary structure to the functional effects of amyloid-β oligomers in the brain.” Neurobiol Aging 35(S1): S2. 2014 (Abstract initially published at the 13th International Athens/Springfield Symposium on Advances in Alzheimer Therapy (AAT), Geneva, Switzerland, 2014.)

Peng Liu, Colleen L. Forster, Linda A. Kotilinek, Jennifer B. Paulson, Yang Xu, Michael K. Lee, Anete Rozkalne, Tara L. Spires-Jones, Bradley T. Hyman, Abdul H. Fauq, Pritam Das, Michael Kuskowski, James P. Cleary, Kathleen R. Zahs, Karen H. Ashe. “Anatomical sequestration of toxic Aβ dimers preserves cognition.” The Society for Neuroscience (SfN) 41st Annual Meeting, Washington DC, 2011.

Peng Liu, Colleen L. Forster, Linda A. Kotilinek, Jennifer B. Paulson, Gang Chen, David A. Bennett, James P. Cleary, Kathleen R. Zahs, Sylvain E. Lesné, Karen H. Ashe. “Aβ dimers mediate plaque-associated cytopathology without affecting cognition.” Alzheimers Dement 7(4), Supplement: e23. 2011 (Abstract initially published at the Alzheimer's Association International Conference (AAIC), Paris, France, 2011.)

Peng Liu, Linda A. Kotilinek, Lisa J. Kemper, Jun Wang, Kathleen R. Zahs, Karen H. Ashe, Giulio M. Pasinetti. “Grape seed polyphenolic extract specifically decreases Aβ 56 in the brains of Tg2576 mice.” Alzheimers Dement 6(4), Supplement: S537. 2010 (Abstract initially published at the Alzheimer's Association International Conference on Alzheimer's Disease (ICAD), Honolulu, Hawaii, 2010.)

Ben M. Dunn, Melissa R. Marzahn, Peng Liu, Hugo Gutierrez-de-Terán, Auther H. Robbins, Robert McKenna. “Plasmepsin 9 as a new target for antimalarial drug discovery.” Biopolymers 92(4): 347. 2009 (Abstract initially published at the 21st American Peptide Symposium, Bloomington, Indiana, 2009.)

Melissa R. Marzahn, Arati Maharaj, Raj Machhar, Bret B. Beyer, Peng Liu, Roxana M. Coman, Ben M. Dunn. “Characterization of novel drug targets from the malaria parasite Plasmodium falciparum.” The 5th International Proteolysis Society (IPS) General Meeting, Patras, Greece, 2007.

Peng Liu, José C. Clemente, Bret B. Beyer, Alfred Chung, Charles A. Yowell, John B. Dame, Ben M. Dunn. “Production and characterization of recombinant PbPM4 and inhibition analysis of combinatorial chemistry derived compounds against PbPM4.” FASEB J 20(4): A47. 2006 (Abstract initially published at the American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Francisco CA, 2006.)

Peng Liu, José C. Clemente, Roxana M. Coman, Charles A. Yowell, John B. Dame, Ben M. Dunn. “Expression and characterization of recombinant PbPM4 and inhibition analysis of HIV protease inhibitors against plasmepsins.” The 4th International Proteolysis Society (IPS) General Meeting, Québec City, QB, Canada, 2005.

Melissa R. Marzahn, Peng Liu, Roxana M. Coman, José C. Clemente, Ben M. Dunn. “Isolation and characterization of recombinant aspartic protease plasmepsin 5 from the Plasmodium falciparum malaria parasite.” The 4th International Proteolysis Society (IPS) General Meeting, Québec City, QB, Canada, 2005.

Peng Liu, Amrita Madabushi, Jennifer Jeung, Chandan J. Kabadi, Linda K. Janka, José C. Clemente, Charles A. Yowell, John B. Dame, Robert McKenna, Sergio Romeo, Mario Dell’Agli, Enrica Bosisio, Ben M. Dunn. “Production of active recombinant PfPM1 and PbPM4 and inhibition analysis with a series of statine-based compounds.” FASEB J 19(4): A863. 2005 (Abstract initially published at the American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Diego, CA, 2005.)

Linda K. Janka, José C. Clemente, Peng Liu, Jennifer Jeung, Chandan J. Kabadi, Charles A. Yowell, Sergio Romeo, Mario Dell’Agli, Enrica Bosisio, John B. Dame and Ben M. Dunn. “Targeting the PM4 orthlogs of Plasmodium sp.” FASEB J 19(4): A863. 2005 (Abstract initially published at the American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Diego, CA, 2005.)

Ben M. Dunn, Bret B. Beyer, Alfred Chung, Peng Liu, José C. Clemente, Linda K. Janka, Jennifer Jeung, and John B. Dame. “Inhibition of plasmepsins by substrate-based peptidomimetics.” J Pept Sci 10(S2):205. 2004 (Abstract initially published at the 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 2004.)

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